Another pathway estrogen might take in prohibiting
schizophrenia is through serotonin receptors.
Researchers have found a decrease in the density of serotonin binding in
schizophrenics, implicating a lack of serotonin activity as a possible
cause of the disease (2). One study has shown that estrogen treatment
in rats that were previously castrated seems to benefit the serotonin transmitter
system in their brain. Possibly estrogen works its beneficial effects
on the schizophrenic brain by increasing serotonin activity.